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Homero Enrique Cárdenas Guillén (13 March 1966 – allegedly died on 28 March 2014), also known by his aliases El Majadero and El Orejón, was a Mexican drug lord and alleged leader of the Gulf Cartel, a drug trafficking organization. He is the brother of the former Gulf Cartel leaders Antonio, Mario, and Osiel Cárdenas Guillen. During the late 1990s, Homero worked for the Gulf Cartel under the tutelage of his brothers. However, after several years of government crackdowns, the Gulf Cartel suffered severe drawbacks, including the death and arrests of Homero's brothers and allies. In August 2013, Homero became the de facto leader of the Gulf Cartel following the arrest of Mario Ramírez Treviño. However, he reportedly died of a heart attack on 28 March 2014.
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