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Isaac Hughes (1798 - 23 June 1870) was an English Calvinist missionary and preacher. He was born to Welsh parents Edward and Mary Hughes in Manchester. His father came from Bontuchel in Denbighshire and his mother came from Brynsiencyn in Anglesey. After some time in Sheffield and Rotherham, he married Elizabeth Jones from Llangollen on August 18, 1823 and departed Britain a month later on September 24 on a ship from Gravesend, arriving in Cape Town, South Africa on December 30. He initially worked as a blacksmith, reaching Kuruman in August 1824 and Griquatown in late 1827, also working in Lattakoo and Graham's Town. In 1839 he became a missionary. In 1845 he worked along the Vaal River and opened a new station in Backhouse. After his wife died, he remarried a missionary's daughter, Anne Magdalena Vogelgezang in 1850. He died on 23 June 1870 after a 47-year career.
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