Mmanthatisi (also spelled 'Ma Nthisi, Mantatise, or Mantatisi; c. 1784 – 1847) was the leader of the Tlokwa people during her son's minority from 1813 until 1824. She came to power as the regent for her son, Sekonyela, following the death of her husband (the previous chief). She led the Tlokwa during the difaqane, the period of mass migration in Southern Africa which saw the tribe move from its original territory in what is now South Africa into present-day Lesotho.
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